Burning pain: axonal dysfunction in erythromelalgia

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Burning pain: axonal dysfunction in erythromelalgia

Erythromelalgia (EM) is a rare neurovascular disorder characterized by intermittent severe burning pain, erythema, and warmth in the extremities on heat stimuli. To investigate the underlying pathophysiology, peripheral axonal excitability studies were performed and changes with heating and therapy explored. Multiple excitability indices (stimulus-response curve, strength-duration time constant...

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ERYTHROMELALGIA is a rare syndrome characterized by episodic burning pain, erythema, and elevated temperature of the feet, hands, or both.[1,2] The syndrome can occur alone or with myeloproliferative or other diseases.[3-5] Attacks may last from minutes to days and can persist indefinitely in the absence of treatment. The pathophysiology of erythromelalgia is poorly understood. Case reports in ...

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ژورنال

عنوان ژورنال: Pain

سال: 2017

ISSN: 0304-3959,1872-6623

DOI: 10.1097/j.pain.0000000000000856